Current Issue : April - June Volume : 2019 Issue Number : 2 Articles : 5 Articles
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are classified\nas two lung complications arising from various conditions such as sepsis, trauma, and lung\ninflammation. Previous studies have shown that the extract of the leaves of Portulaca oleracea (PO)\npossesses anti-inflammatory and anti-oxidant activities. In the present study, the effects of PO..................
Obesity is a condition associated with the accumulation of excess fat in the body, energy\nimbalance, lipogenesis, etc., which increases adipose tissue mass through adipogenesis and poses\na health risk. Its prevalence has become an economic burden to the health care system and the\nworld at large. One of the alternatives to tackling obesity involves the use of bioactive compounds.\nWe critically examined the effects of Hibiscus sabdariffa extract (HSE) on various parameters associated\nwith the development of obesity such as; the effect of HSE on body weight, the effect of HSE on\nlipid accumulation, cholesterol metabolism and plasma parameters, the inhibitory effect of HSE\non pancreatic lipase, and the effect of HSE on adipocyte differentiation/adipogenesis. This review\nhas gathered reports on the various anti-obesity effects of H. sabdariffa bioactive compounds in cell\nand animal models, as well as in humans. Available toxicology information on the consumption\nof H. sabdariffa revealed that its toxicity is dose-dependent and may cause an adverse effect when\nadministered over a long period of time. Reports have shown that H. sabdariffa derived bioactive\ncompounds are potent in the treatment of obesity with an evident reduction in body weight, inhibition\nof lipid accumulation and suppression of adipogenesis through the..............
Sage (Salvia officinalis L.) is a good source of antioxidant compounds, carnosic acid and\ncarnosol being the prominent ones. Both are soluble in CO2, and our goal was to investigate the\napplication of supercritical CO2 extraction to obtain sage extracts rich in these compounds. The effect\nof pressure, temperature, and CO2 flow rate on the carnosic acid and carnosol yield was studied.\nThese variables were optimized by response surface methodology (RSM). The pressure significantly\naffected carnosol extraction, while the extraction of carnosic acid was affected by the pressure,\ntemperature, and CO2 flow rate. Carnosic acid content varied from................
Nigella sativa oil has been known to have potent anti-inflammatory activity. This research\naimed to determine the anti-inflammation activity of Nigella sativa oil in a simple balm stick by topical\napplication. The activity was checked using two methods: carrageenan-induced paw oedema and\ngranuloma pouch on rats. The results showed that balm sticks which contained 10% Nigella sativa\ncould overcome both acute and sub-acute inflammation showing by high oedema inhibition (60.64%),\nlow leucocytes count (43.55% lower than control) as well as a notable���.....
Four previously undescribed compounds, including three rarely occurring seco-dammarane\ntriterpenoid glycosides and a pentacyclic triterpenic acid, were isolated from a 70% ethanol extract of\nthe leaves of Cyclocarya paliurus (Juglandaceae), along with eleven known triterpenoids. Their structures\nwere determined by spectroscopic techniques, including 2D NMR and HRESIMS, as well as chemical\nmethods. Among them, several triterpenoids enhanced insulin stimulated glucose uptake in both\n3T3-L1 adipocytes and C2C12 myotubes. Furthermore, compound 1 dose-dependently increased\nglucose uptake through activating AMP-activated protein kinase (AMPK)-p38 pathway. Collectively,\ntriterpenoids from C. paliurus could be developed as insulin sensitizers, which might have therapeutic\npotential for insulin resistance and hyperglycemia....
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